Drug Combination Shows Huge Promise in Treating Alzheimer’s

It’s against federal law to perform medical experiments on people, so most researchers turn to using other animals – mice, rabbits, dogs and monkeys. Mice are the easiest and cheapest subjects to work with. Scientists have ways of inducing various illnesses in mice, something they wouldn’t do in humans. If their tests don’t work, losing the mice isn’t nearly as big of a deal as losing a person.

However, successes in mice have led to the creation of hundreds of important of medications that have saved countless lives.

Part of the war crimes committed by Nazi Germany was their medical experimentation on prisoners and Jews. They did make some discoveries that helped some areas of medicine, but the testing on living people was cruel and inhumane.

I know many animal protection groups protest against the use of animals, like mice, but without their use, millions of people would die earlier from lack of the important medications that were developed with the help of the mice.

Whether or not you agree with the ethics of using mice to develop effect treatments for humans, consider one such experimental treatment that is showing huge positive results in mice and may lead to benefitting millions of people.

According to a report from Neuroscience News:

“Summary: Senolytic drugs administered to mice reduced senescent cells around amyloid plaques by more than 90% and decreased neuroinflammation by 50%. Mice treated with the drug combination also showed improvements in spatial memory, compared to other Alzheimer’s model mice who received no treatment. The findings could have positive implications for the treatment of Alzheimer’s disease in people with the condition.”

“Source: Johns Hopkins Medicine”

“A study in mice shows that selectively removing cells that are no longer dividing from the brains of mice with a form of Alzheimer’s disease can reduce brain damage and inflammation, and slow the pace of cognitive decline. These findings, say researchers, add to evidence that such senescent cells contribute to the damage caused by Alzheimer’s disease in people.”

“‘Our results show that eliminating these cells may be a viable route to treat Alzheimer’s disease in humans,’ says Mark Mattson, Ph.D., senior investigator in the Laboratory of Neurosciences at the National Institute on Aging and professor of neuroscience at the Johns Hopkins University School of Medicine…”

“Researchers found that a specific brain cell type, called oligodendrocyte progenitor cells, appears in high numbers near plaques. In a healthy brain, oligodendrocyte progenitor cells develop into cells that support nerve cells, wrapping them in a protective layer that heals injury and removes waste. The environment created by the amyloid proteins causes these progenitors to stop dividing and conducting their normal functions. In diseases such as Alzheimer’s, the oligodendrocytes instead send out inflammatory signals that contribute more damage to the surrounding brain tissue.”

Yes, I’ve written about a number of promising discoveries involving Alzheimer’s, but this discovery could be one of the most important of them all. If further tests show the same success rate in mice, it’s bound to receive FDA approval to be used first with some Alzheimer’s patients and then made available to all Alzheimer’s patients.

Hope is better than being hopeless and this study offers some really good hope for the future treatment of one of the top killers of millions of people.

Leave a Reply

Your email address will not be published. Required fields are marked *

Copyright Listabilities, LLC 2018, all rights reserved